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Press Release09 January 2017Process Industries and DrivesNuremberg
Siemens and GEA partner in delivering continuous manufacturing to Pharmaceutical Industry
As an important supplier of process technology and operational systems, GEA has established itself as a leading solution provider in the pharmaceutical industry. The collaboration with Siemens reinforces this global position and now offers life sciences companies — from large multinational organizations to regional specialists and CMOs — an experienced partner to help them implement continuous manufacturing platforms. Comprising GEA's ConsiGmaTM continuous manufacturing platform equipped with a Siemens Automation & Industrial IT solution, including Sipat for PAT Data Management, the combined technologies offer both wet granulation and direct compression in a standard-setting solution for continuous tablet production in the pharmaceutical and life sciences industry.
"Amalgamating our state-of-the-art continuous processing technology with Siemens' automation systems allows us to further support the US Food and Drug Administration's Pharmaceutical Quality for the 21st Century program and help pharmaceutical companies to adopt continuous manufacturing (CM) technologies and modernize their production infrastructure," said Frans Maas, Vice President, APC Pharma Solids, GEA. "Together, our combined experience and expertise will provide significant industry benefits as pharmaceutical manufacturers transition towards continuous manufacturing," he added.
"The use of CM technologies and inline PAT monitoring is a key driver of building quality by design (QbD) into the complete product lifecycle, from R&D through to manufacturing, with the ultimate aim of getting safer medicines to market in a more efficient and cost-effective way," added Hartmut Klocker, Vice President Market Development Board Pharma.
The ConsiGmaTM continuous tableting line is a multipurpose platform that has been designed to transfer powder into coated tablets in development, pilot, clinical and production volumes in a single compact unit. The system can perform dosing and mixing of raw materials, wet or dry granulation, drying, tableting, coating and quality control, all in one line.
From powder to coated tablet, ConsiGmaTM allows pharmaceutical companies to continuously process and manufacture oral solid dosage forms. Offering significant reductions in development time and raw material (API) use, process and energy costs can be considerably decreased using this groundbreaking technology while maintaining quality and increasing manufacturing efficiency.
Simatic Sipat is a scalable and modular software solution that enables companies to extend their PAT-based quality control strategies on a step-by-step basis within the scope of a Quality by Design-based approach. With PAT, product development and production processes can be monitored, controlled and optimized by measuring and calculating the Critical-to-Quality Attributes (CQA's) of the end product in real-time.
This continuous monitoring of product quality can prevent deviations from specifications and therefore reduce production costs. Also, it allows for Real Time Release Testing so that final quality inspections can be reduced or eliminated. Simatic Sipat is Siemens' PAT Data Management solution that integrates PAT activities of an entire line — hence shortening time-to-market significantly.
For more information, please see www.siemens.com/pharma
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About GEA
GEA is one of the largest suppliers for the food processing industry and a wide range of process industries that generated consolidated revenues of approximately EUR 4.6 billion in 2015. As an international technology group, the Company focuses on process technology and components for sophisticated production processes in various end-user markets. The Group generates more than 70 percent of its revenue in the food sector that enjoys long-term sustainable growth. As of September 30, 2016, the Company employed about 17,000 people worldwide. GEA is a market and technology leader in its business areas. The Company is listed in Germany's MDAX (G1A, WKN 660 200). In addition, GEA's share is a constituent of the MSCI Global Sustainability Indexes. Further information is available on the Internet at gea.com.
Siemens AG (Berlin and Munich) is a global technology powerhouse that has stood for engineering excellence, innovation, quality, reliability and internationality for more than 165 years. The company is active in more than 200 countries, focusing on the areas of electrification, automation and digitalization. One of the world's largest producers of energy-efficient, resource-saving technologies, Siemens is a leading supplier of efficient power generation and power transmission solutions and a pioneer in infrastructure solutions as well as automation, drive and software solutions for industry. The company is also a leading provider of medical imaging equipment – such as computed tomography and magnetic resonance imaging systems – and a leader in laboratory diagnostics as well as clinical IT. In fiscal 2016, which ended on September 30, 2016, Siemens generated revenue of €79.6 billion and net income of €5.6 billion. At the end of September 2016, the company had around 351,000 employees worldwide. Further information is available on the Internet at www.siemens.com.
GEA is one of the largest suppliers for the food processing industry and a wide range of process industries that generated consolidated revenues of approximately EUR 4.6 billion in 2015. As an international technology group, the Company focuses on process technology and components for sophisticated production processes in various end-user markets. The Group generates more than 70 percent of its revenue in the food sector that enjoys long-term sustainable growth. As of September 30, 2016, the Company employed about 17,000 people worldwide. GEA is a market and technology leader in its business areas. The Company is listed in Germany's MDAX (G1A, WKN 660 200). In addition, GEA's share is a constituent of the MSCI Global Sustainability Indexes. Further information is available on the Internet at gea.com.
Siemens AG (Berlin and Munich) is a global technology powerhouse that has stood for engineering excellence, innovation, quality, reliability and internationality for more than 165 years. The company is active in more than 200 countries, focusing on the areas of electrification, automation and digitalization. One of the world's largest producers of energy-efficient, resource-saving technologies, Siemens is a leading supplier of efficient power generation and power transmission solutions and a pioneer in infrastructure solutions as well as automation, drive and software solutions for industry. The company is also a leading provider of medical imaging equipment – such as computed tomography and magnetic resonance imaging systems – and a leader in laboratory diagnostics as well as clinical IT. In fiscal 2016, which ended on September 30, 2016, Siemens generated revenue of €79.6 billion and net income of €5.6 billion. At the end of September 2016, the company had around 351,000 employees worldwide. Further information is available on the Internet at www.siemens.com.