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MediaService Digital Industries Newsroom

Biopharmaceuticals: Faster to full scale with simulation – Abec employs advanced simulation software from Siemens to help its customers scale up biopharmaceutical production 

ABEC-biopharmaceuticals-chemical-simulation-digitalization-US

Abec, a supplier of bioreactors and fermenters, employs advanced simulation software from Siemens to help its customers scale up biopharmaceutical production.

Every medicine starts out in a lab, developed and tested in small batches until it is ready to be produced in large quantities – that is, until production can be scaled up. Although not unique to the pharmaceutical industry, the challenges of scaling up from lab-scale experiments to industrial-scale production are critical given the nature and intended use of the products. Abec employs a variety of approaches and methods, including calculations, lab models, testing of production equipment, and computational fluid dynamics (CFD) modeling. In regard to the latter, Abec relies on Siemens Simcenter STAR-CCM+ software.
Thanks to simulation software, Abec has been able to reduce reliance on full-scale experimentation, ensure process stability across sites and platforms, increase the potential for enhanced production yield, and reduce time to market. What’s more, existing systems also benefit, because experiments can be carried out on a digital twin for any given bioreactor configuration to determine opportunities for process improvement.
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Abec has been helping biopharmaceutical companies move from lab-scale experiments to industrial-scale production since 1974.
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Simulation software allows Abec to reduce reliance on full-scale experimentation
ABEC-biopharmaceuticals-chemical-simulation-digitalization-US
Shown are Simcenter STAR-CCM+ simulations of a triple low-shear impeller blender, which are used to simulate the operation of full-scale bioreactor units.

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