medicine starts out in a lab, developed and tested in small batches until it is
ready to be produced in large quantities – that is, until production can be
scaled up. Although not unique to the pharmaceutical industry, the challenges
of scaling up from lab-scale experiments to industrial-scale production are
critical given the nature and intended use of the products. Abec employs a
variety of approaches and methods, including calculations, lab models, testing
of production equipment, and computational fluid dynamics (CFD) modeling. In
regard to the latter, Abec relies on Siemens Simcenter STAR-CCM+ software.
Thanks to simulation software, Abec has
been able to reduce reliance on full-scale experimentation, ensure process
stability across sites and platforms, increase the potential for enhanced
production yield, and reduce time to market. What’s more, existing systems also
benefit, because experiments can be carried out on a digital twin for any given
bioreactor configuration to determine opportunities for process improvement.